This week’s 49ers mailbag is stocked with questions (and answers) regarding their offensive shortcomings, fourth-quarter ...

Injuries always have a significant effect on the NFL season, but some teams are bearing the brunt of absences more than ...

It isn’t news that running back and reigning Offensive Player of the Year Christian McCaffrey is a key cog in the 49ers’ ...

The Kansas City Chiefs are the only undefeated team remaining after seven weeks. The last time the final undefeated team won the Super Bowl was the 2006 Indianapolis Colts.

At linebacker, Dee Winters had his best game of the season while Kyle Shanahan provided a rough timeline for Dre Greenlaw's ...

Several key injuries (and players returning from injuries) are shaking up the NFL -- and fantasy football lineups -- going ...

Even with those ailments of the team’s top three offensive players, the Niners are sizable favorites over the Dallas Cowboys ...

Coach Kyle Shanahan said tests Monday confirmed the initial diagnosis Aiyuk tore his ACL and would need major reconstructive ...

The San Francisco 49ers’ worst suspicions were confirmed Monday when it was learned Brandon Aiyuk was lost for the season ...

The Cowboys have shown a capability of turning things around after a bye week under McCarthy. They are 3-1 after the bye week ...

San Francisco 49ers Brandon Aiyuk has suffered a torn ACL and MCL in his right knee, which will require surgery and end his ...

If the 49ers are serious about winning a Super Bowl this season, they might need to trade for a wide receiver. That's because Brandon Aiyuk is out for the seaso ...