To date, the brain PK of bAbs that target transferrin receptor (TfR-1) and CD98 heavy chain (CD98hc) has been characterized using techniques incapable of distinguishing between CNS clearance of intact ...

Here, the authors prepare N1/N3-histidine modified with 2-hydroxyethylthioethyl using precision synthesis strategies and employ them as external standards to identify the HD-exposed plasma.

This paper examines the mechanism of signal transmission through the histidine kinase PhoQ. The paper nicely describes a model of signaling by allosteric coupling between individual domains rather ...

KCa3.1 is unique among these four channels in that activation requires, in addition to calcium, phosphorylation of a single histidine residue (His358) in the cytoplasmic region, by nucleoside ...