Following the significant losses of players due to injury and illness, including Brandon Aiyuk, San Francisco 49ers head ...

And yet Kyle Shanahan treated it like he treats all games: He played not to lose. So the 49ers lost.

The news around wide receiver Brandon Aiyuk's season-ending knee injury during the San Francisco 49ers' 28-18 loss to the ...

Amid increasing chatter that 49ers running back Christian McCaffrey might make his regular-season debut on Sunday night ...

Finally, it appears that the 49ers have some received some good news from an injury standpoint. On Monday, a day after his ...

San Francisco 49ers head coach Kyle Shanahan told reporters that he would be surprised if star running back Christian ...

San Francisco 49ers head coach Kyle Shanahan said Monday that All-Pro running back Christian McCaffrey has a chance to make ...

The 49ers allowed the Chiefs to rush for 184 yards on 39 attempts, an average of 4.7 yards per carry. They held Patrick ...

The San Francisco 49ers lost their Super Bowl rematch to the Kansas City Chiefs on Sunday, 28-18, but they may have lost a ...

San Francisco 49ers legend Steve Young referenced some outdated school punishment methods when he described the Kyle Shanahan ...