Following the significant losses of players due to injury and illness, including Brandon Aiyuk, San Francisco 49ers head ...

And yet Kyle Shanahan treated it like he treats all games: He played not to lose. So the 49ers lost.

The news around wide receiver Brandon Aiyuk's season-ending knee injury during the San Francisco 49ers' 28-18 loss to the ...

Amid increasing chatter that 49ers running back Christian McCaffrey might make his regular-season debut on Sunday night ...

Finally, it appears that the 49ers have some received some good news from an injury standpoint. On Monday, a day after his ...

San Francisco 49ers receiver Deebo Samuel attempted to play through an illness during Sunday's loss to the Kansas City Chiefs ...

San Francisco 49ers star wide receiver Deebo Samuel attempted to give it a go Sunday against the Kansas City Chiefs. He's ...

San Francisco 49ers head coach Kyle Shanahan told reporters that he would be surprised if star running back Christian ...

San Francisco 49ers head coach Kyle Shanahan said Monday that All-Pro running back Christian McCaffrey has a chance to make ...

The strength of the San Francisco 49ers’ offense the past few seasons has been the number of dynamic playmakers that makes it ...

Talanoa Hufanga, an All-Pro safety in 2022, has played in just one game after recovering from a torn ACL, was felled by a ...