The superfamily 1 (SF1) and SF2 enzymes are non-hexameric enzymes possessing both helicase and single-stranded DNA (ssDNA) translocase activities, as well as the ability to displace proteins from DNA.

to understand how E1 replication machines assemble, translocate on DNA and separate DNA base pairs. Helicases, particularly those belonging to superfamily 1 and 2 have roles in the DNA damage and DNA ...

DExH‐box helicase 58; DNAJB4, DnaJ heat shock protein family (Hsp40) member B4; ECM1, extracellular matrix protein 1; EFEMP1, EGF‐containing fibulin‐like extracellular matrix protein 1; F2, ...

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States Department of Pharmacology, University of ...

Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China CAS-HKU Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong, Pokfulam ...

Figure 5. Schematic diagram of critical proteins required for the replication and transcription of mtDNA. TWINKLE is an mtDNA helicase that catalyzes the unwinding of duplex DNA using energy from NTP ...

Cancer is one of the leading causes of death worldwide. Many therapies are being used to treat this disease, however, new treatments are now being implemented, since they are not always effective and ...