C&EN14d
Comparative Radiotracing Quantifies Brain Cellular Uptake and Catabolism of Bispecific Antibodies Targeting Transferrin Receptor and CD98hc
To date, the brain PK of bAbs that target transferrin receptor (TfR-1) and CD98 heavy chain (CD98hc) has been characterized using techniques incapable of distinguishing between CNS clearance of intact ...
C&EN28d
Human Untargeted Metabolomics in High-Throughput Gut Microbiome Research: Ethanol vs Methanol
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States Collaborative Mass Spectrometry Innovation Center, University of ...
Frontiers23d
ROS signaling in innate immunity via oxidative protein modifications
Hydroxyl radicals, upon interaction with tryptophan and histidine, form hydroxytryptophan and 2-oxohistidine, respectively (46). Highly oxidized proteins appear to be relatively poor substrates for ...
Frontiers23d
Multiomics insights on the onset, progression, and metastatic evolution of breast cancer
Pathways upregulated in breast cancer include glycolysis; metabolic pathways such as pyruvate fatty acid, arginine and proline, and valine, leucine and isoleucine catabolism; protein ubiquitination; ...
Cancer Research24d
Gut Microbiota–Mediated hsa_circ_0126925 Targets BCAA Metabolic Enzyme BCAT2 to Exacerbate Colorectal Cancer Progression
1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China. 2Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, China. 7Suzhou Biomedical ...
eLife14d
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, United States; Department of Microbiology, UMass Chan Medical School, United States; ...