Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ ...

Whether stereotactic body radiotherapy (SBRT) is noninferior to conventionally or moderately hypofractionated regimens with respect to biochemical or clinical failure in patients with localized ...

Combination chemotherapy has been the standard treatment for advanced-stage Hodgkin’s lymphoma for decades. Chemotherapy backbones differ worldwide, with doxorubicin, bleomycin, vinblastine, and ...

Hairy-cell leukemia (HCL) is a rare, indolent neoplasm of mature B cells with hairlike surface projections that circulate in the blood and preferentially infiltrate the bone marrow and spleen.

Treatments for Dupuytren’s contracture include limited fasciectomy and collagenase injection. Comparisons of the effectiveness of these treatments have been limited. We performed an unblinded ...

Dr. Lucas X. Marinacci: A 72-year-old woman was evaluated for dysarthria and respiratory failure during an admission to this hospital, which had occurred before the coronavirus disease 2019 pandemic.

Cerebral adrenoleukodystrophy is a severe form of X-linked adrenoleukodystrophy characterized by white-matter disease, loss of neurologic function, and early death. Elivaldogene autotemcel (eli ...

Dr. Danielle C. Crabtree (Medicine): A 37-year-old man was admitted to this hospital because of fever, myalgia, jaundice, and hypoxemia. The patient had been healthy until 9 days before this ...

In this Double Take video from the New England Journal of Medicine, Dr. Nathaniel Morris (University of California San Francisco) examines the complex relationship between mental health and ...

Gene therapy with elivaldogene autotemcel (eli-cel) consisting of autologous CD34+ cells transduced with lentiviral vector containing ABCD1 complementary DNA (Lenti-D ...

Respiratory syncytial virus remains a serious cause of illness in older persons. In this follow-up report of the RENOIR trial, efficacy of the RSVpreF vaccine is assessed over a second season.

The appropriate duration of beta-blocker therapy after uncomplicated myocardial infarction is unclear. Although some evidence suggests no benefit of long-term use, randomized trials are lacking.