Researchers have uncovered a source of "replication stress" during DNA replication, shedding light on a new cancer target.

However, that requires us to understand the molecular architecture of DNA helicase. Coordination of DNA Unwinding and Replication is Essential Why is coordination between DNA unwinding and ...

Credit: James Graham/UC Davis When a DNA molecule replicates an enzyme called "helicase" unzips the double ... to form another double helix. In DNA replication, the "leading" strand forges ahead ...

Replication is the process by which a double-stranded DNA molecule is copied to produce two identical DNA molecules. DNA replication is one of the most basic processes that occurs within a cell.

This is particularly true of the viral E1 protein, which is a replication initiator protein and hexameric replicative helicases. The role of the helicase in replication is to separate the strands of ...

Dysregulated R-loops can cause stalled replication forks and telomere instability ... discovered that ILF3 interacts with several DNA/RNA helicases, including DHX9. This interaction suggests ...

In previous work, using the reconstituted DNA replication system, we have identified the molecular functions for the effector kinase, Rad53, in controlling fork progression and origin activation by ...

The presence of precatenanes behind replication forks in vivo implies that replicative helicases generate tension that outpaces the relaxing ability of topoisomerases (forks can travel at an ...