Courtesy of Roger J. Pomerantz and the Center for Human Virology and Biodefense ©2003 John Wiley & Sons, Ltd. Dicer cleaves exogenous or endogenous double-stranded RNA (dsRNA) into 21–25-nucleotide ...
Dicer also processes long dsRNA molecules into small interfering RNA (siRNA) duplexes. Only one strand of the miRNA:miRNA* duplex or the siRNA duplex is preferentially assembled into the RNA ...
Viroid replication generates dsRNA intermediates, which are processed by Dicer into 21- to 25-nucleotide siRNAs. These siRNAs are then incorporated into siRNA – ribonuclease complexes (RISC). If the ...
The double-stranded RNA is processed by an RNase III family enzyme Dicer, resulting in the generation of an siRNA, a 21–23-nucleotide (nt) RNA duplex, composed of a 19-mer sequence with ...
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