1). Dicer is unlikely to be such an endonuclease because it generates 5′-monophosphate rather than 5′-triphosphate groups. The ERI-1 exonuclease, which limits the RNAi response, is an ...

Jeang, Yamina Bennasser, and colleagues characterized a sequence in the HIV-1 genome that encodes a rare siRNA precursor: a short hairpin RNA (shRNA) that is processed by the Dicer (or by a Dicer-like ...